


11/11/2025
This is a procedure note for Rejuran's PN: Unveiling Its Effects and Identifying Suitable Candidates. at Beomgye(Opening Soon) KKEUT Korean Clinic.
Rejuran PN Skin Booster: What exactly is the PN ingredient?
Let's explore the expected benefits and suitable candidates for this treatment.
Understanding the Rejuran PN Injection
Rejuran Treatment: Its Core Principles and Components

The main component of Rejuran injection is PN (Polynucleotide).
PN is a DNA fragment, or nucleic acid, sourced from salmon. When administered into the skin, it helps promote the regeneration of compromised skin cells and re-establish a healthy cellular environment.
This means it offers more than transient hydration; it is a procedure designed to rebuild the skin's fundamental capacity for self-healing.
PN initiates cell regeneration and concurrently stimulates fibroblasts, which can contribute to collagen synthesis.
Within the skin, anti-inflammatory and antioxidant activities unfold simultaneously, potentially fostering a healthier overall skin environment.
Expected Outcomes with Rejuran PN Treatment
Restoring Skin Barrier and Minimizing Moisture Depletion
– PN aims to restore the compromised stratum corneum and the dermal-epidermal junction, potentially reinforcing skin barrier function.
– With a stabilized barrier, transepidermal water loss may decrease, which can alleviate dryness, assisting the skin in maintaining its natural hydration.
Alleviating Inflammatory Responses and Reducing Erythema
– PN modulates the activity of inflammatory cytokines, which may lead to a reduction in redness and frequency of eruptions on irritated skin.
– This treatment may be considered for individuals with sensitive skin or those prone to rosacea. The regeneration process post-treatment tends to be relatively swift.
Encouraging Collagen Production and Enhancing Skin Suppleness
– By engaging fibroblasts, it can facilitate the generation of collagen and elastin. This mechanism may aid in refining pores, softening the appearance of fine lines, and restoring a sense of intrinsic skin firmness.
Comprehensive Enhancement of Skin Texture and Radiance
– Through the process of cellular regeneration, rough and lackluster skin texture may evolve to become smoother and more uniform.
– Consistent treatments can progressively enhance the skin's inherent capacity for self-repair.

Individuals with delicate, sensitive skin who often observe instances of redness or facial flushing.
Those experiencing profound dryness, where their skin continues to feel taut internally despite regular moisturizing efforts.
Individuals noticing a general reduction in skin suppleness across areas like pores, fine lines, and overall skin texture.
Patients who find their skin exhibits a prolonged recovery period or heightened fragility subsequent to laser or other dermatological treatments.
Individuals who aspire to foster healthy skin regeneration from its deeper layers.