This is Gyeonggi Anyang Beomgye KKEUT Korean Clinic's procedure note on NP Rejuran: The Principle and Interval You Should Know Before Treatment.
What people considering NP Rejuran most want to know first is how it changes the skin and how far apart the sessions should be.
Knowing the principle and the interval before treatment makes the questions to ask at consultation much clearer.
This article walks through, in order, how Rejuran-type skin boosters work and the criteria for the number of sessions, as organized by Kkeut Oriental Medicine Clinic.

What ingredient does Rejuran deliver?
Rejuran is a PN (polynucleotide) type skin booster.
It delivers polynucleotide extracted and purified from the DNA of salmon or trout milt into the dermis.
To understand the principle, it makes sense to start with the role this ingredient plays inside the skin.

The first role is strengthening the skin's own regenerative ability.
It helps repair damaged tissue and activates fibroblasts to induce the production of collagen and elastin.
The aim is to improve the environment in which the skin regenerates by itself.
The second role is soothing and water retention.
Along with an anti-inflammatory action, it raises water retention and contributes to improving skin texture and elasticity.

It is often confused with fillers, but the purpose is different.
A filler fills in missing volume, whereas Rejuran is a skin booster concept that improves the quality of the skin itself.
If the goal is to fill hollow areas, whether Rejuran is the right choice should be discussed first at the consultation.
What concerns is it used for?
Its indications are broad: fine lines, reduced elasticity, skin texture, pores, soothing redness and sensitive skin, and even lines around the eyes.
It is intended for damaged or aged skin and for skin in general that needs recovery after procedures.
Its ingredient and mechanism differ from other skin boosters.
Rejuran is PN, Juvelook is PLLA-based collagen stimulation, and exosome is based on stem cell-derived signaling substances.
Exosome is best suited to inflammatory concerns such as acne, acne scars and redness, and Juvelook to pores and acne scars.
Rejuran falls on the side of improving the overall skin environment, such as hydration, elasticity, pores and redness.

Treatment process and delivery methods
The process runs in this order: cleansing, numbing cream application, dermal injection or channel formation followed by application, and soothing.
One session takes about 20 to 30 minutes on average.
Delivery methods are divided into manual hand injection, MTS and stamp, needle RF, pumping tip and others.
Hand injection causes stinging, slight swelling, redness and injection marks, which usually settle within 1 to 3 days.
Downtime is short, but there is some pain.
Applying after creating channels is classified as a method with less pain and lower risk of nodules compared with injection.

How is the interval set?
The general recommendation is 3 to 4 cumulative sessions at 2 to 4 week intervals.
After that, you move on to maintenance care depending on your skin condition.
With Rejuran, the regenerative effect becomes clearer through cumulative treatment rather than a single session.
When you notice results and how long they last vary with your skin condition.
The right number of sessions is most accurately decided at the consultation after looking at your skin.
On the day of treatment, avoid activities that raise body heat, such as saunas, drinking alcohol and strenuous exercise.
Moisturize well and be thorough with sun protection.

Three criteria to check before getting Rejuran
These days, as the patent has expired, skin boosters with the same PN ingredient under various names are appearing.
Even with different names the PN ingredient is the same, so how it is injected and how consistently you can keep receiving it matter more than the name when choosing.
The first criterion is consistency.
PN is an ingredient that matters most when received consistently, so a place that offers lower-cost options you can comfortably continue is a good fit.
Kkeut Oriental Medicine Clinic offers reasonably priced options based on the fact that this is a cumulative treatment.

The second criterion is checking for embossing.
PN is only meaningful when injected into the dermis, and having received an injection does not guarantee that it reached the dermis.
When PN enters the dermis, the skin rises in a raised bump called embossing, which is a sign that the medication went into the dermis well.
Kkeut Oriental Medicine Clinic shows you this embossing directly in a mirror after treatment.

The third criterion is having a choice of treatment methods.
Methods are divided into hand injection, the Potenza pumping tip, the Dermashine injector and others, so you should be able to choose according to your pain tolerance and skin condition.
Kkeut Oriental Medicine Clinic decides together with you which of these methods suits your preference and treatment area.

Frequently asked questions
Q. Is NP Rejuran the same kind of treatment as a filler?
A. NP Rejuran has a different purpose from fillers, which add volume. Rejuran-type products are skin boosters aimed at skin regeneration and quality improvement. At Kkeut Oriental Medicine Clinic, we first discuss whether it is the right treatment for your concern.
Q. How is the NP Rejuran treatment interval set?
A. For NP Rejuran, the general recommendation is 3 to 4 cumulative sessions at 2 to 4 week intervals. Maintenance afterward is decided according to your skin condition. At Kkeut Oriental Medicine Clinic, we look at your skin condition at the consultation and advise on the number of sessions.
Q. Will NP Rejuran get in the way of daily life afterward?
A. NP Rejuran has fairly short downtime, and redness, swelling and injection marks usually settle within 1 to 3 days. On the day, avoid saunas, alcohol and strenuous exercise, and take care with moisturizing and sun protection.
The sincerity of Kkeut Oriental Medicine Clinic
Kkeut Oriental Medicine Clinic delivers differentiated results through a consistent cumulative treatment plan at an affordable price.
Kkeut Oriental Medicine Clinic raises patient satisfaction by showing you the embossing in a mirror after treatment.
Kkeut Oriental Medicine Clinic pursues both safety and effectiveness through a choice of methods among hand injection, the Potenza pumping tip and the Dermashine injector.
One small difference, a different result — Experience it at Kkeut Oriental Medicine Clinic.
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