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Painless Rejuran: 3 Ways to Reduce Pain Even Without Sleep Anesthesia

Painless Rejuran: 3 Ways to Reduce Pain Even Without Sleep Anesthesia Beomgye, Pyeongchon, Beomgye Station, Pyeongchon Station, Hogye-dong, Bisan-dong, Gwanyang-dong, Dongan-gu, Indeogwon, Geumjeong, Anyang

6/25/2026

This is a procedure note for Painless Rejuran: 3 Ways to Reduce Pain Even Without Sleep Anesthesia at Beomgye(Opening Soon) KKEUT Korean Clinic.

Painless Rejuran, you can reduce pain even without sleep anesthesia



There's a common question asked before a Rejuran (PN Skinbooster) procedure: 'Does it hurt a lot?' Those who have experienced the manual injection method are particularly concerned about stinging and post-procedure swelling, often hesitating about their next session. This is why the term 'painless Rejuran' is gaining attention. There are certainly ways to reduce the perception of pain even without sleep anesthesia, and Kkeut Clinic outlines these methods in three categories.







What is Rejuran (PN Skinbooster) treatment?



Rejuran is a skin booster that delivers Polynucleotide (PN) components, extracted and refined from salmon and trout testicle DNA, into the dermal layer. Instead of simply adding volume like fillers, it helps regenerate damaged tissues and activates fibroblasts to induce collagen and elastin production. It's a concept focused on improving the skin's intrinsic regeneration environment.



The indications are broad. It is widely used for overall signs of aging such as fine wrinkles, reduced elasticity, poor skin texture, enlarged pores, redness, soothing sensitive skin, and fine lines around the eyes, as well as for skin requiring recovery after other procedures. While exosomes focus on inflammation and troubles, and Juvelook (PLLA) on pores and acne scars, PN-based Rejuran focuses on improving hydration, elasticity, and overall skin environment.







Generally, 3-4 cumulative treatments at intervals of 2-4 weeks are recommended. Since the regenerative effects become more pronounced with cumulative treatments rather than single sessions, consistency is key. Nowadays, as patents for PN-based products have expired, brand names have diversified, but the essence of the ingredient remains the same: the delivery of polynucleotides to the dermal layer.







Method to reduce pain 1 — Change the delivery method



The biggest factor influencing pain perception during Rejuran treatment is the delivery method. There are roughly three main methods: manual injection, Potenza Pumping Tip, and DermaShine (injector).



Manual injection offers high precision, allowing direct injection to the desired depth and location, but it is also the method with the strongest pain perception. Redness, swelling, and injection marks may persist for 1-3 days after the procedure. In contrast, the Potenza Pumping Tip or DermaShine methods involve needles creating channels, after which the medication is delivered to the dermal layer. These are known to result in lower pain and nodule risk compared to manual injection. If you desire painless Rejuran, choosing the delivery method is the starting point.







Method to reduce pain 2 — Ensure sufficient application time for anesthetic cream



Anesthetic cream primarily acts on the skin surface. While it cannot completely block sensation deep within the hair follicles and dermis, ensuring sufficient absorption time after application can significantly reduce the initial stinging sensation during the procedure. Generally, an absorption time of 20-30 minutes or more is recommended. If the procedure time is tight and the anesthetic cream application time is short, the perceived pain will differ greatly, even with the same cream. The second condition for painless Rejuran is the absorption time of the anesthetic cream.







Method to reduce pain 3 — Verify dermal layer injection



While not directly related to pain, there is a crucial verification point that determines the completeness of the procedure: Embossing. Embossing is the phenomenon where the skin in the treated area visibly rises in a convex manner when the PN component is accurately injected into the dermal layer. The appearance of this phenomenon is evidence that the medication has properly entered the dermal layer.



Confirming embossing is a process that guarantees the treatment's effectiveness. Simply undergoing the procedure doesn't guarantee accurate dermal layer injection. Choosing a clinic that shows you the embossing in a mirror after the procedure is directly linked to achieving actual results. If you want to reduce pain while also ensuring effectiveness, it's crucial to confirm beforehand if the clinic verifies dermal layer injection.







A structure that allows for consistent treatment is more important than painless Rejuran



For Rejuran (PN-based treatments), consistent accumulation is more crucial than a single powerful session. If you discontinue treatment midway due to pain, the regenerative effects won't build up. If your reason for wanting painless Rejuran is ultimately 'to receive it continuously,' then an environment where you can comfortably receive treatment with manageable pain and affordable options is more important. If the price is a burden, it's difficult to adhere to the recommended intervals, and the results will also differ.







Post-treatment care is simple. On the day of the procedure, avoid heat stimulation such as saunas, alcohol, and strenuous exercise. Simply moisturize sufficiently and apply sunscreen diligently. It's considered a procedure with a short downtime, allowing for a quick return to daily life.







Frequently Asked Questions



Q. If it's called painless Rejuran, does it truly not hurt at all?


A. Painless Rejuran does not mean 'zero pain.' It's a concept that minimizes the perception of pain by optimizing the delivery method and anesthetic cream absorption time. At Kkeut Clinic, the method is chosen among manual injection, pumping tip, and DermaShine based on the skin condition and pain sensitivity.



Q. Does painless Rejuran yield the same results?


A. Even if the delivery method differs, if the PN component is accurately delivered to the dermal layer, the effects are the same. Kkeut Clinic verifies dermal layer injection through embossing confirmation after the procedure. Different methods do not diminish the effect.



Q. How do Rejuran, Exosomes, and Juvelook differ?


A. They differ in ingredients and mechanisms of action. Rejuran (PN-based) is optimized for improving hydration, elasticity, and overall skin environment; Juvelook (PLLA) for pores and acne scars; and Exosomes for inflammation, redness, and troubles. A consultation is necessary to choose the right option for your current skin concerns.



Q. How many sessions of painless Rejuran are needed to feel the effects?


A. Generally, 3-4 cumulative treatments at intervals of 2-4 weeks are recommended. Even with painless Rejuran, the improvement in hydration and elasticity becomes more pronounced with consistent accumulation rather than single sessions. While changes in skin texture can be felt after just one treatment, the regenerative effects become stronger with each accumulated session.







Kkeut Clinic's Sincerity



Kkeut Clinic provides an environment where patients can choose the method that best suits their skin condition and pain sensitivity among manual injection, Potenza Pumping Tip, and DermaShine (injector). Giving patients the choice of method is the starting point for painless Rejuran.



Kkeut Clinic performs embossing confirmation as a standard procedure after treatment. Only by confirming through a mirror that the PN component has actually been injected into the dermal layer can the treatment received be linked to its effects. Without visual confirmation, it's impossible to know if the dermal layer injection was successful.



Kkeut Clinic places importance on a pricing structure that allows for consistent treatment. As cumulative treatments are key for PN-based products, we maintain reasonable options to ensure that treatment cycles are not interrupted due to price burden. Consistent accumulation changes the skin more effectively than a single high-cost treatment.



A subtle difference, a significant result — Experience it at Kkeut Clinic.